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    Dianabol is the synthetic form of the anabolic steroid and was first introduced to cycling in the 70’s, used by Lance Armstrong.

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    Replacement of the list of 23 steroids with a list of 59 steroids, including both intrinsically active steroids as well as steroid metabolic precursors, was not motivated by a desire to increase research on endogenous steroids, since the list of 59 steroids on which substitution was possible is identical to the list of those known to be endogenous. Substitution of the list of 59 steroids with a list of 39 steroids has been shown to lead to a greater decrease in specificity for the 17α-candrostene steroid (17α-androstanediol). An increase in sensitivity for the naturally-occurring estrogen 17β-estradiol has been shown with the addition of 17 androstanediol to a drug test. We have used the same test to demonstrate that substitution of the list of 23 steroids with that of 37 steroids, including both intrinsically-active steroids as well as steroid metabolic precursors, causes a decrease in specificity for 17α-hydroxylated estrogens. The sensitivity for the naturally-occurring 17β-estradiol and the other naturally-occurring estrogen estrone has not been measured. These two test measures are differentially sensitive for the different steroid estrogens and might act as a further confounding factor. Our results suggest that a different steroid list would lead to a different sensitivity to natural estradiol (17β-estratrienol) and synthetic estradiol (17α-ethyltestosterone); hence, the use of both sets of steroid lists would be a useful approach to confirm the use of synthetic estrogens (Figure 1). In the current study, substitution of the list of 23 steroids with both lists caused no change in sensitivity or specificity of the test for estradiol. This finding agrees with earlier reports indicating that the sensitivity was unchanged after the addition of the list of 38 steroids to the list of 23, which did not influence specificity of the test for estradiol [9], [10].

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